Cloxacillin Sodium for Injection

Active Pharmaceutical Ingredient	CAS NO.	Molecular Formula	Definition	Structural Formula
Cloxacillin Sodium	642-78-4	C19H17ClN3NaO5S	(2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Sodium Salt Monohydrate

Description:

Cloxacillin Sodium For Injection is a sterility powder supplied in an airtight container. It is a white or almost white, odourlous, hygroscopic , crystalline powder.

API mixing

Filling

Vial sterilization

Cloxacillin Sodium is bactericidal with a mode of action similiar to that of benzylpenicillin, but is resistant to staphylococcal penicillinase.

It is active therefore against penicillianse-producing and non penicillianse-producing staphylococci, with minimum inhibitory concentrations in the range of 0,25 to 0,5 ug per ml. Ist activity against strepococci such as strepto- coccus pneumoniae and Str. Pyogenes is less than that of benzylpenicillin , but sufficient to be useful when these organisms are present with penicillin-resistant staphylococci. Cloxacillin Sodium is virtually ineffective against enterococcus faecalis.

Cloxacillin Sodium is an isoxazolyl penicillin used primarily for the treatment of infections due to staphlococci resistant to Benzylpenicillin. These include bone and joint infections, endocarditis, peritonitis (associated with continious ambulatory Peritoneal dialysis), pneumonia, skin infections ( including doft-tissue infections), and toxic shock syndrome.

It is administered by mouth or by injection as the sodium salt. By mouth it should be given at least 30 minutes before meals as the presence of food in the stomach reduces absorption. All doses are expressed in terms of the equivalent amount of Cloxacillin.

Usual doses are 500mg four times daily by mouth or 250mg by intramuscular injection every 4 to 6 hours or 500mg may be given by slow intravenous infusion (add 2ml Water for Injection before use)

All systemic doses may be doubled in severe infections.

Cloxacillin Sodium has also been administered by intra-articular or intrapleural injection, and by inhalation.

Children up to 2 years of age may be given one quarter of the adult dose and those aged 2-10 years , one half of the adult dose.

Cloxacillin Sodium For Injection may be administered in combination with other antibacterials, including ampicillin, to produce a wider spectrum of activity. Cloxacillin Benzathine is used as veterinary medicine.

Administration can also be made according to medical order and physican's prescription.

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