Procaine Penicillin for Injection

Active Pharmaceutical Ingredient	CAS NO.	Molecular Formula	Definition	Structural Formula
Procaine penicillin G	54-35-3	C29H38N4O6S	Hydrogen (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 2-(diethylamino)ethyl 4-aminobenzoate (1:1:1)

Procaine Penicillin For Injection is a sterile powder composed of procaine benzylpenicillin (also known as procaine penicillin G) and suitable suspending agents. Here are the key details:

Composition:

Procaine Penicillin For Injection: A combination of procaine (a local anesthetic) and benzylpenicillin (a β-lactam antibiotic).

Chemical name: Procaine benzylpenicillin (6R)-6-(2-phenylacetylamino)-penicillanic acid salt monohydrate.

Molecular formula: C13H20N2O2·C16H18N2O4S·H2O

Molecular weight: 588.72

API mixing

Filling

Vial sterilization

Indications:

Limited to mild to moderate infections caused by highly penicillin-sensitive pathogens:

Streptococcal infections (e.g., tonsillitis, scarlet fever)

Pneumococcal pneumonia

Furuncles caused by penicillin-sensitive Staphylococcus aureus

Early-stage syphilis

Relapsing fever

Dosage and Administration:

Administered by intramuscular injection.

Dosage varies based on infection severity and patient age.

Freshly prepare the suspension before use.

Adverse Effects:

Common: Allergic skin reactions (e.g., rash, urticaria), transient leukopenia.

Rare: Anaphylactic shock (requires immediate treatment).

Precautions:

Perform skin testing for penicillin allergy before use.

Cross-allergies may occur with other penicillins or cephalosporins.

Adjust dosing in renal impairment.

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