Chemical Information
Chemical Name: (6R,7R)-7-[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt.
Molecular Formula: C₁₈H₁₈N₈O₇S₃·2Na (disodium salt)28.
CAS No.: 104376-79-628.
Appearance: White to off-white crystalline powder.
Storage & Handling
Storage: Preserve in tightly closed containers, protected from light, at 2–8°C.
Solubility: Freely soluble in water (≥50 mg/mL).
Applications
Primary Use: Active pharmaceutical ingredient (API) for third-generation cephalosporin antibiotics, effective against Gram-positive and Gram-negative bacteria.
Therapeutic Indications: Used in formulations targeting severe infections (e.g., sepsis, meningitis), respiratory/urinary tract infections, and surgical prophylaxis.
Sterility: For injectable formulations, requires sterility or further processing under aseptic conditions.
Safety & Stability
Hygroscopic: Sensitive to moisture; requires inert atmosphere during storage.
Impurities: Monitor for isomers (e.g., USP Ceftriaxone Sodium E-isomer RS).
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