APIs

Indications‌

Used for infections caused by β-lactamase-producing bacteria resistant to piperacillin but susceptible to the combination, including:

‌Moderate to severe infections‌: Appendicitis (with perforation/abscess), peritonitis.

‌Skin/soft tissue infections‌: Cellulitis, skin abscesses, diabetic foot infections.

‌Respiratory infections‌: Moderate community-acquired pneumonia, hospital-acquired pneumonia.

‌Urogenital infections‌: Postpartum endometritis, pelvic inflammatory disease.

‌Other‌: Sepsis, bone/joint infections, intra-abdominal abscesses.

‌Dosage and Administration‌

‌Adults and children ≥12 years‌:

Standard dose: 4.5 g (piperacillin 4 g + tazobactam 0.5 g) every 8 hours via IV infusion or IM injection.

Hospital-acquired pneumonia: Initial dose of 4.5 g every 6 hours; may combine with aminoglycosides.

‌Renal impairment‌: Adjust dose or extend dosing interval.

‌IV infusion‌: Reconstitute with 20 mL diluent, then dilute in 250 mL compatible fluid (e.g., 5% glucose); infuse over ≥30 minutes.

‌Contraindications‌

Hypersensitivity to penicillins, cephalosporins, or β-lactamase inhibitors.

Use cautiously in severe hepatic/renal dysfunction, pregnancy, and lactation.

‌Adverse Reactions‌

‌Common‌: Rash, pruritus, diarrhea, nausea, vomiting.

‌Occasional‌: Elevated liver enzymes, pseudomembranous colitis, renal impairment, injection-site pain.

‌Rare‌: Anaphylaxis.

‌Drug Interactions‌

Synergistic effect with aminoglycosides (e.g., amikacin, gentamicin) against certain Gram-negative bacteria.

‌Key Precautions‌

Perform penicillin skin testing before administration.

Prolonged use may lead to superinfections (e.g., fungal or resistant bacteria).

Available as an injectable powder; included in national medical insurance formularies.

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