Indications
Used for infections caused by β-lactamase-producing bacteria resistant to piperacillin but susceptible to the combination, including:
Moderate to severe infections: Appendicitis (with perforation/abscess), peritonitis.
Skin/soft tissue infections: Cellulitis, skin abscesses, diabetic foot infections.
Respiratory infections: Moderate community-acquired pneumonia, hospital-acquired pneumonia.
Urogenital infections: Postpartum endometritis, pelvic inflammatory disease.
Other: Sepsis, bone/joint infections, intra-abdominal abscesses.
Dosage and Administration
Adults and children ≥12 years:
Standard dose: 4.5 g (piperacillin 4 g + tazobactam 0.5 g) every 8 hours via IV infusion or IM injection.
Hospital-acquired pneumonia: Initial dose of 4.5 g every 6 hours; may combine with aminoglycosides.
Renal impairment: Adjust dose or extend dosing interval.
IV infusion: Reconstitute with 20 mL diluent, then dilute in 250 mL compatible fluid (e.g., 5% glucose); infuse over ≥30 minutes.
Contraindications
Hypersensitivity to penicillins, cephalosporins, or β-lactamase inhibitors.
Use cautiously in severe hepatic/renal dysfunction, pregnancy, and lactation.
Adverse Reactions
Common: Rash, pruritus, diarrhea, nausea, vomiting.
Occasional: Elevated liver enzymes, pseudomembranous colitis, renal impairment, injection-site pain.
Rare: Anaphylaxis.
Drug Interactions
Synergistic effect with aminoglycosides (e.g., amikacin, gentamicin) against certain Gram-negative bacteria.
Key Precautions
Perform penicillin skin testing before administration.
Prolonged use may lead to superinfections (e.g., fungal or resistant bacteria).
Available as an injectable powder; included in national medical insurance formularies.
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