APIS
|
Active Pharmaceutical Ingredient |
CAS NO. |
Molecular Formula |
Defination |
Structural Formula |
|
Amoxicillin and Clavulanate Potassium Tablets |
26787-78-0 |
C16H19N3O5S |
[2S-[2a,5a,6b(S*)]]-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid |
|
Product Specifications
|
Products |
Specification |
Vomume of vials |
Packing form |
|
Amoxicillin and Clavulanate Potassium Tablets 312.5mg; 375mg; 457mg; 562.5mg; 625mg; 1000mg |
USP latest version |
White round tablet |
5tabs/blister, 3blisters/box |
Lower respiratory tract infection
It is caused by Haemophilus influenzae and Moraxella catarrhalis which produce β -lactamases.
Upper respiratory tract infection (including ear, nose and throat)
It is caused by Haemophilus influenzae and Moraxella catarrhalis which produce β -lactamases.
Skin and soft tissue infections
Caused by strains of Staphylococcus aureus, Escherichia coli and Klebsiella producing β -lactamases.
Urinary system infection
Caused by Escherichia coli, Klebsiella and Enterobacter producing β -lactamases.
Some strains in the pathogenic genus of the above diseases produce β-lactamase, which makes them insensitive to amoxicillin alone. When using, you should refer to the official guiding principles of clinical application of antibacterial drugs.



Dosage
Adults and children weighing ≥40kg, take one tablet three times a day. Without re-examination, the continuous treatment period does not exceed 14 days.
Oral. It should be taken with meals and should not be chewed, so as to minimize the potential gastrointestinal intolerance and achieve the best absorption.



Matters need attention
Before starting to take Ampicillin and Clavulanate Potassium Tablets, patients must first have a penicillin skin test.
Allergic to cephalosporins and allergic diseases such as asthma, eczema, hay fever, urticaria and severe liver dysfunction with caution.
There is cross-allergy between this product and other penicillins and cephalosporins. If allergic reaction occurs, stop using this product immediately and take corresponding measures. It has been reported that patients treated with penicillin have experienced severe and occasional fatal allergic reactions (anaphylactic shock), which is more likely to occur in patients with a history of penicillin allergy. In case of allergic reaction, the use of amoxicillin-clavulanic acid should be stopped and appropriate alternative treatment should be carried out. Severe allergic reactions require immediate emergency treatment with epinephrine. Oxygen infusion, intravenous steroid infusion and airway management, including intubation, may also be required.
This product is cross-resistant to ampicillin and other penicillins and cephalosporins.
Estimate the glomerular filtration rate is less than 30ml/min with caution, renal failure should be adjusted according to the glomerular filtration rate dose or administration interval; Hemodialysis can affect the blood concentration of amoxicillin in this product, so this product should be taken once after hemodialysis.
When using high-dose amoxicillin, it is suggested that patients should take enough liquid and ensure enough urine output to reduce the possibility of amoxicillin crystallized urine.
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