APIS
| Active Pharmaceutical Ingredient | CAS NO. | Molecular Formula | Definition | Structural Formula |
| Benzathine Penicillin | 41372-02-5 | C48H64N6O12S2 | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsäure--N,N'-dibenzylethan-1,2-diamin(2:1)tetrahydrat |
|
Products Specications
| Products | Specification | Vomume of vials | Packing form |
| Benzathine Penicillin for Injection 1.2mega,2.4mega |
BP | 7ml mould vials | 50vials/box |
| 10vials/box | |||
| 25vials/box | |||
| 1vial/box | |||
| 10ml mould vials | 50vials/box | ||
| 10vials/box | |||
| 1vial/box | |||
| 1+1WFI/box | |||
| 12ml mould vials | 50vials/box | ||
| 1+1WFI/box | |||
| 15ml mould vials | 50vials/box | ||
| 25vials/box |
Each vial contains 1.2 MIU ( 0.9 g) or 2.4 MIU ( 1.8 g) Benzathine Penicillin For Injection.
Preparation;
Benzathine penicillin 1.2 MIU: add 4 ml water for injection to the vial.
Benzathine penicillin 2.4 MIU: add 8 ml water for injection to the vial.
Shake vigorously until a homogeneous suspension is obtained.
Uses:
Benzathine Penicillin For Injection is a long-acting benzylpenicillin salt with the same antimicrobiological action as benzylpenicillin. It gives bloodlevels for 2 - 4 weeks after IM injection, but much lower than benzylpenicillin sodium. It is therefore restricted to highly susceptible micro-organisms. Acute infections should be treated initially with benzylpenicillin sodium. Benzathine benzylpenicillin is an antibiotic which is effective in streptococcal, pneumococcal and treponemal infections. It is used in the treatment of infections which are highly sensitive to penicillin and which require longterm treatment: syphilis, pneumonia, leptospirosis, yaws and pinta. Prevention of rheumatic fever.
Dosage
Administer by deep intramuscular injection.
| Early syphilis | 2.4 MIU, in a single dose, usually as 2 injections at separate sites |
| Late syphilis | 1 - 2 doses of 2.4 MIU, at weekly intervals for 3 - 5 consecutive weeks |
| Congenital syphilis in infants up to 2 years | 50,000 IU/kg bodyweight in a single dose |
| Other infections | Adults 1.2 or 2.4 MIU once a week |
| Children < 12 years 0.6 MIU daily or at intervals of 3 days or 1.2 MIU at intervals of 2 - 4 weeks | |
| Prevention of rheumatic fever | Adults 1 - 2 doses of 1.2 MIU, at intervals of 4 weeks |
| Children < 12 years0.6 MIU at intervals of 14 days or 1.2 MIU at intervals of 4 weeks |
Pregnancy and breast feeding:
Penicillins are not known to be harmful when used during pregnancy. Benzathine penicillin is excreted in breast milk and could cause sensitization in the infant.
Contra-indications and warnings:
Do not use in patients with known penicillin allergy. Use only with care in patients with renal impairment.
Concomitant use of probenecid, indometacine and salicylates in high doses reduces excretion of penicillins.
Side effects:
Hypersensitivity includes skin reactions, edema in the throat, seldom anaphylactic shock.
In patients with syphilis Jarish-Herxheimer reaction may occur at the start of the treatment due to release of endotoxins from the killed treponemes. Pain and inflammation at the injection side.
Overdosage:
Symptoms: benzathine penicillin is not toxic, even in high doses. In allergic patients, anaphylactic shock, haemolytic anaemia and allergic nephropathy can be life-threatening.
Treatment: treatment of shock (administration of adrenaline, restoration of blood pressure).
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