Cefuroxime Sodium for Injection

Composition of Cefuroxime Sodium for inection:

Each vial contains: Cefuroxime Sodium USP equivalent to 750mg or 1.5g Cefuroxime.

API mixing

Filling

Vial sterilization

Cefuroxime is a bactericidal semi-synthetic cephalosporin antibiotic which is resistant to most ß-lactamases and is active against a wide range of Gram-positive and Gram-negative organisms. Peak serum levels of cefuroxime are reached within 30 ~45 minutes after intramuscular administration. The serum half-life after either intramuscular or intravenous injection is about 70 minutes. Concurrent administration of probenecid produces an elevated peak serum level and restricts the excretion of the antibiotic. There is almost complete recovery of unchanged cefuroxime in the urine within 24 hours of administration the major part being eliminated within the first 6 hours. The tubular excretion component of renal clearance of cefuroxime is of the order of 50%.

It is indicated that Cefuroxime sodium for injection is for the treatment of the following infections when caused by susceptible strains of the designated micro-organisms:

Respiratory tract infections

Ear, nose and throat infections

Urinary tract infections

Bone and joint infections

Soft tissue infections

Obstetrics and gynaecological infections

Gonorrhoea

Prophylaxis against infection in abdominal, cardiac and pulmonary surgery where there is an increased risk of infection.

 

Sensitivity tests should be carried out for wherever possible. Cefuroxime is active in vitro against:

Staphylococcus aureus including penicillin-resistant strains but not the rare methicillin-resistant strains

Escherichia coli

Klebsiella spp

Enterobacter spp

Streptococcus pyogenes

Streptococcus viridans

Clostridium spp

Proteus mirabilis

Proteus rettgeri

Proteus vulgaris

Proteus morganii

Neisseria spp - including ß-lactamase producing strains of N. gonorrhoea

Haemophilus influenzae

Bacteroides fragilis

In vitro sensitivity does not necessarily imply in vivo efficacy.

Cefuroxime is contra-indicated in patients with a known hyper-sensitivity to cephalosporins.

The safety in pregnancy and lactation has not been established.

Hot Tags: cefuroxime sodium for injection, China cefuroxime sodium for injection manufacturers, suppliers, factory, penicillin solid preparations, Ceftazidime For Injection, Oxacillin Sodium For Injection, cephalosporin powder injection, Procaine Penicillin For Injection