Products Specifications

Products	Specification	Vomume of vials	Packing form
Furosemide Injection	BP latest version	2ml brown/transparent ampoule	10 or 100 amps/box

API mixing

Filling

Vial sterilization

Product Introduction

Product Overview

Furosemide Injection, also known as Flurocemide Injection, is available in a 2ml: 10mg formulation. It is a highly effective loop diuretic used to manage various conditions associated with fluid retention and high blood pressure.

Therapeutic Indications

Furosemide is primarily indicated for the treatment of edema associated with:

Congestive heart failure

Pulmonary edema

Renal insufficiency

Hepatic disorders

Additionally, it is used in managing hypertension, either as a standalone treatment or in combination with other antihypertensive agents. Furosemide is also beneficial in treating severe hypercalcemia by promoting urinary calcium excretion, especially in patients who do not respond to thiazide diuretics.

Mechanism of Action

Furosemide acts rapidly after intravenous administration, with effects visible within about 5 minutes and lasting for approximately 2 hours. It works by inhibiting the reabsorption of sodium, potassium, and chloride ions in the ascending limb of the loop of Henle and the distal renal tubules. This inhibition leads to increased excretion of these electrolytes and water, thereby reducing fluid retention.

Furosemide has no significant effect on carbonic anhydrase. Its terminal elimination half-life is around 2 hours but can be prolonged in neonates and patients with renal or hepatic insufficiency. It is highly bound to plasma albumin (up to 99%) and is mainly excreted in the urine, largely unchanged. Non-renal elimination increases significantly in renal failure. Furosemide crosses the placental barrier and is excreted in breast milk. Hemodialysis does not enhance its clearance.

Clinical Efficacy

Furosemide Injection is highly effective in reducing edema and controlling blood pressure. Its rapid onset of action makes it particularly useful in emergency situations where quick fluid removal is needed, such as in acute pulmonary edema. It is also effective in patients with severe hypercalcemia, aiding in the excretion of excess calcium through urine.

Manufacturing and Quality Control

Furosemide Injection is produced under stringent quality control measures to ensure its safety and efficacy. The manufacturing process includes precise formulation with suitable excipients to maintain stability and potency. Each batch undergoes rigorous testing for purity, potency, and sterility to meet regulatory standards.

Packaging and Logistics

Flurocemide Injection is available in 2ml ampoules, packaged in boxes containing 10 or 100 ampoules. The packaging is designed to protect the product from light and physical damage during storage and transportation. Furosemide Injection is distributed under controlled conditions to ensure its stability and effectiveness upon delivery to healthcare facilities.

FAQ

Q: What are the main uses of Furosemide Injection?

A: It is used to treat edema associated with heart failure, pulmonary and renal conditions, hepatic disorders, and hypertension. It is also used to manage severe hypercalcemia.

Q: How does Flurocemide Injection work?

A: Furosemide inhibits the reabsorption of sodium, potassium, and chloride in the kidneys, increasing the excretion of these electrolytes and water, thus reducing fluid retention.

Q: How quickly does Furosemide Injection work?

A: The effects of Furosemide Injection are evident within about 5 minutes after intravenous administration and last for approximately 2 hours.

Q: What are the potential side effects?

A: Side effects may include electrolyte imbalance, dehydration, low blood pressure, and ototoxicity, particularly with high doses or rapid administration.

Q: Are there any contraindications?

A:Furosemide should not be used in patients with hypersensitivity to it or other sulfonamides, severe electrolyte depletion, anuria, or in patients with hepatic coma and precomatose states.

Administration and Dosage

Furosemide Injection is administered intravenously. The typical dose ranges from 10mg to 40mg, depending on the severity of the condition and the patient's response. The dose may be adjusted based on the clinical scenario and patient needs.

Warnings and Precautions

It is essential to monitor electrolyte levels, kidney function, and fluid balance regularly to avoid complications such as electrolyte imbalance and dehydration. Furosemide should be used with caution in patients with severe renal impairment or those prone to electrolyte disturbances.

Logistics and Supply Chain

Furosemide Injection is distributed worldwide, ensuring timely availability in hospitals and clinics. The logistics process involves maintaining a controlled temperature environment to preserve the medication's integrity. The robust packaging ensures that the product remains intact and effective from the point of manufacture to the end user.

Furosemide Injection is an essential medication for managing edema and hypertension, offering rapid and effective relief with a well-established safety profile. Its quick action and efficacy make it a preferred choice in various acute and chronic conditions requiring diuretic therapy.

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