Gentamycin Sulfate Injection

Specification: 2ml:20mg; 2ml:40mg; 2ml:80mg; 2ml:280mg
Therapeutic indications:
This product is used to treat sepsis, lower respiratory tract infection, intestinal infection, pelvic infection, abdominal infection, skin soft tissue infection, complex urinary tract infection, etc. The combination of gentamicin and other antibacterial drugs is commonly used in clinic. In combination with penicillin (or ampicillin), enterococcal infections are treated. It is also used for central nervous system infection caused by sensitive bacteria, such as meningitis, ventriculitis, can be used at the same time intrathecal injection as an auxiliary treatment.

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APIS

Active Pharmaceutical Ingredient	Latin Name	Molecular Formula	Defination	Structural Formula
Gentamycin Sulfate Injection	Gentamycin Sulfate Iniectio	C(19-21)H(39-43)N5O7·H2SO4	O-2-Amino-2,3,4,6,7-pentadeoxy-6-(methylamino)-a-D-ribo-heptopyranosyl-(1®4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1®6))-2-deoxy-D-streptamine

Product Specifications

Products	Specification	Vomume of vials	Packing form
Gentamycin Sulfate Injection	BP latest version	Colorless to slight yellow or slightly yellowish green, clarity liquid	10amps/tray, 10trays/box

Dosage

Intramuscular injection or intravenous infusion after dilution for adults, 80mg (80,000 units) once, or 1-1.7mg/kg once per body weight, once every 8 hours; Or 5mg/kg once, once every 24 hours.
Children intramuscular injection or diluted intravenous drip, once 2.5mg/kg, once every 12 hours; Or 1.7mg/kg once every 8 hours. The course of treatment is 7-14 days, during which blood concentration should be monitored as much as possible, especially in newborns or infants.
The dosage of patients with renal dysfunction: according to normal renal function once every 8 hours, a normal dose of 1-1.7mg/kg, creatinine clearance rate of 10-50ml/min, once every 12 hours, a dose of 30-70% of the normal dose; When creatinine clearance is <10ml/min, 20-30% of the normal dose is given every 24-48 hours.

API mixing

Filling

Vial sterilization

Adverse effect

Occasionally dizziness, insomnia, lethargy, nausea, diarrhea, constipation, rash, muscle pain and other symptoms. Arrhythmia, elevation of transaminase, changes of renal function, granulocytopenia, etc. may occur when large doses are used.

Matters need attention

It may cause hearing loss, tinnitus or ear fullness and other ototoxic reactions, affecting vestibular function can occur instability, vertigo. Nephrotoxic reactions such as hematuria, significantly reduced frequency of urination or decreased urine volume, decreased appetite, and extreme thirst may also occur. Low incidence of neuromuscular block or renal toxicity caused by dyspnea, lethargy, weakness and so on. Occasionally, skin rash, nausea, vomiting, hypohepatic function, leukopenia, granulocytopenia, anemia, hypotension, etc. Hearing loss, tinnitus or ear fullness and other ototoxic symptoms may occur in a small number of patients after stopping the drug, which should be noticed. Systemic administration combined with intrathecal injection may cause leg convulsions, rash, fever and general convulsions.

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