Introduction to suppositories

Suppository refers to a solid preparation of a drug with a suitable matrix and a certain shape for intraluminal administration in the human body. Suppositories are solid at room temperature, and after being inserted into the lumen, they can quickly soften and melt or dissolve in secretions at body temperature, gradually releasing drugs and producing local or systemic effects.
Suppository refers to a solid preparation of a drug with a suitable matrix and a certain shape for intraluminal administration. Suppositories are solid at room temperature, and after being inserted into the lumen, they can quickly soften and melt or dissolve in secretions at body temperature, gradually releasing drugs and producing local or systemic effects. In the early days, people believed that suppositories only had local effects such as lubrication, convergence, antibacterial, insecticidal, and local anesthesia. Later, it was discovered that suppositories could also exert systemic effects through rectal absorption of drugs and avoid the first pass effect of the liver